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December 30, 202429 min

PN Deep Dive: Happy New Year! The Magic of Stem Cells, The Emperors of Rome, Huberman on Happiness, Micky Malka, David Senra and Danny Hillis

Get more notes at https://podcastnotes.org NEW Premium Notes5 Ways Stem Cells Will TRANSFORM What It Means To Be Healthy | The Gabby Reece Show Christian Drapeau (@stemcellchristian) is a pioneer in stem cell research. And the first to propose stem cells as the body’s innate repair system. Christian Drapeau discusses the transformative potential of stem cells in health and healing. They explore the basics of stem cells, their role in the body, the evolution of stem cell research, and the impact of aging on stem cell efficacy.The Roman Caesars’ Guide to Ruling | Barry Strauss on The Art of Manliness with Brett McKay (#1047) How often do you think about the Roman Empire? Lately, this question has gone viral, leaving many women wondering why their husband or boyfriend is reflecting on Roman history so often. The truth lies in the Empire’s enduring allure: its epic tales of power, war, ambition, innovation, and dramatic leadership. In these Premium Podcast Notes, we turn to historian Barry Strauss who gives a detailed overview of his book, Ten Caesars: Roman Emperors from Augustus to Constantine, unpacking the themes that make Rome’s legacy a timeless source of fascination.Podcast Notes Book Collection: 2024 Edition (UPDATED AND COMPLETE with 200+ Books)After reviewing all 400+ Podcast Notes we wrote in 2024, we selected a comprehensive reading list of over 200 books. Whether you’re a new parent, hopeful entrepreneur, tech geek, history buff, or just a general bookworm, there’s truly something for everyone!Top Takeaways Of The Week5 Ways Stem Cells Will TRANSFORM What It Means To Be Healthy | The Gabby Reece Show Stem Cells With Age: By age 30, you’ve lost 90% of red marrow stem cells; as stem cells disappear from the body, the loss becomes increasingly apparent over timeStem cell sources: Bone marrow, fat tissue, blood, umbilical cordYamanaka factor: Take old cells and turn them into cells with characteristics of young cellsWhy We Lose Them: “Over the past 150 years, we’ve gained an extra 50 years of lifespan. I don’t think we have the biology to have an extra 50 years naturally with full blossoming health. We need to kind of hack and tap and leverage things in our body.” – Christian DrapeauStem cells from blood (like PRP) are very potent; they’re dormant so need to be ‘awakened’. This is likely the future of stem cells and relatively new to use; the task now is to learn how to isolate and grow them for use Stem cells from the umbilical cord: The most potent – but not as mainstream because of three notable concerns:* (1) Risk of contaminated stem cells is high which can lead to sepsis;* (2) They’re difficult to isolate cleanly;* (3) You can obtain genetic material from a donor who may have been a carrier for a disease that you may develop in the futureTips to Supported Stem Cells:* Red lights might help with bodily repair, possibly by aiding blood circulation* Pulsed magnetic frequency (PMF) has been well-documents to boost stem cell frequency* Exercise releases stem cells – but this might be because if you trigger tissue damage, your body will trigger a response* Quality sleep supports the proliferation of brain stem cells* Meditation has a healing component – 20 minutes of meditation has been shown to encourage stem cell release* Plants for health: Shilajit, black seed (periodically), natto, kava (hard to source)The Roman Caesars’ Guide to Ruling | Barry Strauss on The Art of Manliness with Brett McKay (#1047) The Rise of Octavian/Augustus Caesar: Octavian, born Gaius Octavius, was Julius Caesar’s grand-nephew and was adopted posthumously as part of Caesar’s will — which was technically illegal, but law was pretty loose during civil warHow to Win the Game of Thrones: Augustus simply killed off a lot of his enemies, between several civil wars and the execution of about 100 Roman senatorsAugustus' Expansion: Octavian added Egypt, northwestern Spain, and Switzerland to the Roman EmpireThe Infamy of Nero: Nero was less interested in the empire itself and more interested in the celebrity of being Emperor* He was egotistical and also very vain about his singing and chariot racing ability* He competed in the Panhellenic Games and “won” every eventThe Truth About Nero's Fiddling While Rome Burned: There’s a rumor that Nero fiddled while Rome burned, but the fiddle technically hadn’t been invented yet. However, he may have played a lyre, which is a harp-like instrument.* There are even rumors that claim Nero started the fire, with the intent to engage in a massive urban renewal projectMarcus Aurelius, the Ivory Tower Emperor: Marcus Aurelius was a great philosopher but not a great emperor* Marcus Aurelius had no military experience or experience outside Italy, he was completely unprepared to become empowered — a common theme in the Roman Empire system* He let is son Commodus follow him as emperorCommodus, The Villain: The first man born to be emperor* Commodus was arrogant, entitled, and irresponsible* Competed as a gladiator* He offered bread and circuses to the people but killed many senators* Eventually, the senate carries out a plot to kill CommodusDr. Laurie Santos: How To Achieve True Happiness Using Science-Based Protocols | Huberman LabHappiness Operates on 3 Timescales: (1) The immediate timescale of happiness; (2) The intermediate timescale of happiness where we introduce a story; (3) Meaning which is the full pictureTips to Approach Happiness on All 3 Levels:* Engage in activities that fit with values and strengths;* Infuse strengths into work & leisure;* Do for others* Ask others for helpExtrinsic rewards: A tangible, visible reward for achieving somethingIntrinsic rewards: Reward comes from within, feeling progress, purpose, etc.On the lower end of the income spectrum, money affects happiness: If you struggle to put food on the table, keep a roof over your head – more money almost has a linear relationship with happinessStop being a Sad Loner: One of the biggest levers you can pull to improve happiness is to get more social connection“The two things that predict whether you’re happy or not so happy are how much time you spend with friends and family members and how much you are physical around other people. The more of that you do, the happier you’re going to be.” – Laurie SantosDopamine Must Be Earned, Not Given: “Be wary of any dopamine hit not preceded by effort to achieve it.” – Andrew HubermanPrediction error: Introverts predict social connection will be negative, when in actuality they get report a great experience; extroverts predict social connection will be ok, and anticipation is highNegativity bias: We’re built to notice the risky, potentially scary stuff; our brain goes there automatically which makes sense evolutionarilyToxic Positivity: The notion that something is wrong if you’re feeling anything but happy or ‘good vibes’; negative emotions are a cue from our body to take action in some direction to fixDog vs. Cat People: If you crave unconditional love, you are probably more of a dog person; cats are more independentHedonic adaptation: We get used to things; you can’t be happy all the time because you become sensitized* “Every good thing in life becomes boring after some time.” – Laurie Santos* Tip: Imagine the negative things and obstacles; use worse things as a comparison to realize how good things are – don’t ruminate on it but use your imagination to appreciate what you have* Tip #2: Space out positive experiences to come back to them over timeBanister effect: Believe something is positive; be optimistic enough to think something is doable then ask yourself the question ‘what will get in the way?’ so you problem-solveArrival fallacy: The idea, “I’ll be happy when…” – the thing we arrive at doesn’t feel as good once we get there and we chase the next thingMicky Malka – Building Ribbit | Invest Like the Best with Patrick O’Shaughnessy Ep. 400 Life and business principles from Micky Malka:* 1. Never forget where you came from* 2. Fewer decisions is best* 3. Be genuine to yourself and those around youLessons learned from the Robinhood saga* Being the CEO is a very lonely existence* Develop and craft a flexible mindset so that you can be comfortable taking risk* When you truly understand the variables at play, you will be more comfortable with taking ‘risk’* Mistakes made in a single day can damage a company’s brand for years to comeTechnologies have their own grid complexes* The electrical grid consists of towers, power meters, transformers, and more* The internet is a grid of data and knowledge* The monetary system has its own grid as well, consisting of the different financial layers and rails which include Visa, Mastercard, SWIFT, etcStablecoins: US dollar stablecoins are travel checks in today’s world; they are instant dollars that the individual can control and move, anytime, and for zero* Stablecoins provided people with access to US dollars who previously did not have access to dollars and who were forced to use their local (and weaker) fiat currency* Today, US-dollar stablecoins do a similar monthly volume to that of Visa and MastercardWhat Got You Here, Won't Get You There: Burn the bridge that got you here; whatever got you here will not get you to the next phaseGet the full notes at Podcastnotes.org Thank you for subscribing. 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January 30, 202540 min

PN Deep Dive: Huberman Lab Sleep Collection: Protocols & Science

Get more notes at https://podcastnotes.org Podcast Notes Premium Collection: Huberman and SleepGet the FULL NOTESIntro to Sleep* Sleep cycles & Architecture: non-REM and REM play for brain domination throughout the night in 90-minute cycles – this is the standard architecture of sleep* Ratio of non-REM and REM throughout the night: the first half of the night is dominated by non-REM deep sleep; the second half of our sleep is dominated by REM sleep* Not everyone’s sleep cycles are 90 minutes: sleep architecture is fairly consistent within a person, but can be different across people* Non-REM Sleep: Non-REM deep sleep is divided into four stages, increasing in the depth of sleep: stages 1 and 2 are light stages of non-REM deep sleep; stages 3 and 4 are deep stages of non-REM deep sleep* In stages 1 and 2: the heart rate begins to drop, and brain wave activity slows down* In stages 3 and 4: the heart rate is low, cells in the cortex fire together then go silent* During non-REM deep sleep, we get autonomic restoration and regulation of heart rate and blood pressure* Hypnogogic Jerks: during stage 1 you experience mini dreams s you’re starting to drift off and can almost wake yourself up in this stage – sometimes you experience a jerk in your body as a result of loss of proprioceptive feedback* Don’t miss these notes about how Salvador Dali used the hypnogogic state to be creative (Slumber with a Key)* …Quantity, Quality, Regularity, and Timing (QQRT): The macros of sleep* Quantity: the average adult needs between 7-9 hours of sleep per night – but the reality is more complex* Quantity alone doesn’t tell the full story* …Carbs, Caffeine and THC* Carbs in AM vs. PM: research does seem to support that your body is better able to metabolize carbohydrates in the morning versus evening if you’re concerned about your blood sugar and metabolic health* Eating Before Bed: In gener…Sleep Supplements* Magnesium Threonate or Glycinate, 145mg, 30-60 minutes before sleep* Magnesium chloride can be effective for bioavailability by way of muscle relaxation* Apigenin: 50mg, 30-60 minutes before sleep* Theanine: 100-400mg, 30-60 minutes before sleep (Do NOT take Theanine if you are prone to night terrors or sleepwalking)* Inositol* Glycine: 1.5-2gPhosphatidylserine will dampen cortisol response* Check out the full Momentous Huberman sleep stack & use promo code PODCASTNOTES for 15% off at checkout!Sleep Tips* 1. Do Nothing! If you are struggling with sleep and had a bad night of sleep, do not sleep in later, do not go to bed earlier, do not increase caffeine intake, do not compensate with a nap* 2. Time rescheduling/sleep restriction therapy: if you are spending too much time in bed, your brain is not efficient; it’s like being in the gym for hours a day but spending most of the time scrolling on your phone – you’re not really getting a good workout like if you know you only have 45 minutes to workout* 3. Don’t underestimate the importance of a winddown routine: whatever you enjoy for relaxation, build it into your regimen to help you decelerate* 4. Do NOT count sheep, instead take yourself on a mental walk: counting sheep actually makes you stay awake longer; instead, get your mind off itself by going through a rudimentary walk with hyper-detail – imagine putting your shoes on, opening the door, crossing the street, imagine the signs you see, look at the flowers, etc.* 5. Remove …* Monophasic sleep: Single bout of sleep in 24 hour period* Biphasic sleep: Two bouts of sleep in 24 hour period* Polyphasic sleep: …Napping* Naps are a Double-Edged Sword: If you struggle with sleep at night, do not nap during the day in order to build up sleepiness and hopefully sleep at night* Cons of Napping: Naps remove sleep pressure (adenosine) so if you struggle with sleep, you are setting yourself up for worse sleep because you’ve removed some of the sleepiness you need* Pros of Napping: If napping does not disrupt your sleep and leaves you feeling better, go ahead and nap but be cautious of napping too late which can disrupt sleep* Are Naps Right F…* Super Charged Nap: Swig espresso right before napping + nap 20 minutes + cold water to hands and face upon waking + immediate daylight 5-10 minutes outside3 Ways Sleep is Essential for Learning:* 1: We need sleep before learning to start the initial imprint and laying the tracks; sleep before learning is critical* 2: We also need sleep after learning to cement the information in our brain* 3: We need sleep to integrate the new information with previously learned information we have stored* Exactly How Much an All-Nighter Impacts Memory: Pulling an all-nighter leads to deficits of up to 40% in making new memories* …* Symptoms of REM Sleep Deprivation: Paranoia, hallucination, aspects of psychosis (with enough time)* Bad Sleep, And Then: When sleep deprived, you’re excessively reactive and hypersensitive, particularly to reward-based activities – dopamine circuits are overactive when you are underslept* Sleep and Addiction: A lack of sleep is associated with addiction potential AND relapse if trying to abstain* REM Sleep Killers: Alcohol, THC* One Possible Mechanism for PTSD: The brain is trying to process the traumatic experience but fails, so the brain tries again the next night, and the next – until …Brain Features of REM:* (1) Electrical brain wave activity in the cortex is similar to that when you are awake;* (2) There are unique pulses from the brain stem ultimately to the occipital cortex (linked to rapid eye movements);* (3) Motor regions, visual regions, memory-related structures, and emotional-related structures of the brain all light up* (4) The dorsolateral prefrontal cortex (responsible for inhibition and planning) activity is suppressed during REM* Functions of REM sleep: (1) Creativity; (2) Emotional & mental wellness – REM sleep is overnight therapy* …* (1) Consistently rehearse the notion that you will remember your dreams and you will take control of your dreams – if you do this enough, the probability you will induce lucid dreams is high* (2) Rehearse something (like flicking a light switch on and off) over and over; Then, when this appears in your dream you can take control* …Get the FULL NOTES Thank you for subscribing. 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March 29, 2026

The 3 Signs of Human Genius • Leonardo da Vinci's Annunciation (Video)

Creative Codex: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Discover the 3 Signs of Genius through a journey into the mind of Leonardo da Vinci. What made Leonardo so brilliant? We will venture deeper than anyone else to find out through the most comprehensive analysis of Leonardo da Vinci's first masterpiece: Annunciation.Support the Creative Codex vision and get access to exclusive episodes (Kurt Cobain, Jung's Red Book, Creativity Tips, etc.) by joining my Patreon: https://www.patreon.com/c/mjdorianCreator's Note: No A.I. was used in the production of this video. This includes: no image generation, no text generation, and no music generation. ALL of the art imagery was made by human artists and is credited accordingly throughout the video on the lower right side of the screen. All research, writing, and music is by MJDorian with no assistance from generative A.I. at any point in the production process.Audio Editor: Erik TexterAnimation: Michael PisanoConnect with Michael Pisano: https://www.michaeljamespisano.com/ Instagram: https://www.instagram.com/papa_pisanoInstagram: https://www.instagram.com/thatmakesmesadWritten & Produced by MJDorianMusic by MJDorianConnect with MJDorian:Instagram: https://www.instagram.com/mjdorianYouTube: https://youtube.com/@creativecodex?si=To9hmuUQmuPlb8gNCopyright 2026All rights reserved.

October 27, 202412 min

PN Deep Dive: Oct. 28 Newsletter

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October 25, 202416 min

PN Deep Dive: Post-2020 Survival Guide: Modern Mental Models for Navigating Society and Understanding the Self

Get more notes at https://podcastnotes.org We live in a brave new world, one that requires modern tools. Social media algorithms are more manipulative than ever. Meanwhile, mainstream media distorts the truth, deepening public skepticism and confusion. Since 2020, much has changed — some of it irreconcilable. Those of us who can master the new landscape will thrive, but those who fail to adapt will fall further behind. That’s why Podcast Notes Premium has curated this Modern Survival Guide, offering practical mental models and insights on prioritizing truth-seeking, understanding the self in today’s society, navigating politically charged conversations, avoiding social media traps, and keeping pace with a world that seems to be moving at an unprecedented and erratic pace. Thank you for subscribing. Leave a comment or share this episode.

April 28, 202517 min

PN Deep Dive: 📝 Secrets to Public Speaking Mastery, Hubervision, Peter Thiel, Exercise Science, Rich Barton - Zillow, HuberAddiction, True History of Native Americans

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January 28, 202511 min

PN Deep Dive: 📝 David Deutsch, Scott Galloway, _Mike Cernovich, _Jensen Huang, 2X Huberman, and Tyler Cowen

Get more notes at https://podcastnotes.org Time Saved This Week: 8 Hours, 53 MinutesNEW Premium NotesDavid Deutsch: Chemical Scum that Dream of Distant Quasars | TED In this TEDTalk from 2005, David Deutsch (@DavidDeutschOxf) was tasked with going out on a limb and saying something surprising. The result? A profound exploration titled Chemical Scum That Dream of Distant Quasars where he redefines humanity’s place in the universe and celebrates the limitless potential of human knowledge. Though the title might sound nerdy or even a bit intimidating, these Premium Podcast Notes break down every element of this groundbreaking TED Talk, revealing powerful principles of problem-solving that could transform how you see your role in fostering the endless growth of knowledge and shaping a better future.Scott Galloway on How Stoicism Can Benefit Young Men | Daily Stoic with Ryan HolidayScott Galloway on "Intergenerational Theft" and why Stoicism can help young men who are struggling now more than ever. Go Premium to learn why young men are struggling, how to protect the middle class, the value of being a Nation, how to be successful, truths about money and more.Mike Cernovich – Escaping Sam Altman’s Techno-Slavery | Zero Hour with James PoulosMike Cernovich discusses Sam Altman's Techno-Gnostic archetype, secular fatalism, Greco-Roman principles, consciousness, and more. This is not your average podcast and not to be missed.Upgrade to Premium to Get 3 Premium Notes Every Week, the Full Newsletter, Playable Timestamps, AI Powered Answers, Unlock 500+ Premium Posts, No Ads and MOREGo PREMIUMTop Premium Takeaways Of The WeekDavid Deutsch: Chemical Scum that Dream of Distant Quasars | TED Is Earth Special? Two Possible Theories…* Theory #1: Earth is very untypical and uniquely suited...* “Spaceship Earth” = ...* If we destroy the ...* Theory #2: Earth is typical and human beings are not ...* “The human race is just a chemical scum on a moderate-sized planet, orbiting around a very average star in the outer suburb of ...” – Stephen Hawking* Key Takeaway: “So, especially if you regard them as deep truths to form cornerstones of your world view and inform your life-decisions, they appear somewhat in ...” – David DeutschEarth is Very Not Typical: “Deep, intergalactic space is completely dark. It is so dark that if you were to look at the nearest star to you, and that star were to explode as a supernova, and you were staring directly at it at the moment when its light reached you, then ...”– David DeutschHumans are Very Special Chemical Scum: “Therefore we are chemical scum that’s different. This chemical scum has universality. Its structure contains, with ever-increasing ...” – David Deutsch* “The fact that the laws of physics permit – and even mandate – ...” – David Deutsch3 pre-requisite resources for the open-ended creation of knowledge:* Matter: the growth of knowledge is a ...* Energy: the inputs required to ...* Evidence: the laws of physics saturate the ...Resources are abundant, knowledge is scarce: If something isn’t forbidden by the ...Our Sacred Responsibility as Humans: “Species go extinct. All the time. Civilizations end. The vast majority of all species and all civilizations that have ever existed are now history. If we want to be exceptions ...” – David DeutschScott Galloway on How Stoicism Can Benefit Young Men | Daily Stoic with Ryan HolidayThe Epicenter of Today’s Problem: For the first time in the nation’s three-century history, a thirty-year-old person today is doing worse than ...* “When the majority of kids aren’t doing as ...” – Scott GallowayThe nation is a feature, not a bug: The most successful people in tech should have more ...Understanding Power Laws and the Pareto Principle: A very small percentage of people will ...Advice for young people on how to be successful: Put yourself in rooms of ...The trope “money can’t buy happiness” is a myth: Studies show that middle-income people are ...Young Men Are In Trouble: Young men in America are ...* 4x more likely to kill themselves* Four out of five suicides involve men* There is a certain amount of resentment and ...Understanding Stoicism: Stoicism is a philosophy that teaches ...Why Billionaires Become Billionaires (narrative violation): Generally, billionaires are good high-character people; one of ...Emotional advice from Scott: * If something moves you, lean into that emotion and learn how to cry* Figure out a way to ...* Lean into feeling your ...* To not lean into ...* You will get to know ...Mike Cernovich – Escaping Sam Altman’s Techno-Slavery | Zero Hour with James PoulosThe Fallacy of Pendulum Theory: There is no law of the universe that says things have to swing back and forth between ...* The political right tends to have a certain ...America has submitted to its base-lower impulses * Book recommendation: Nicomachean Ethics by Aristotle* Many Americans have lost touch with what ...* It would be one thing if people turned away from God but...The Source of Society's Problems: Alienation from the divine is...* Understand that there are ...Techno-Gnostics refers to a perspective or philosophy combining elements of technology with ...* We can’t just take our consciousness, ...The Harsh Truth About Sam Altman: “Sam Altman is a gnostic, but he doesn’t realize that he’s 2,000 years too late. Hating your body and thinking that your body is gross is not some sort of new thing.” – Mike Cernovich* “Sam Altman hates being a human and wishes he didn’t live in a body and wants to upload himself into a Warhammer machine. People like that – I think we should dismiss ...” – Mike Cernovich* Like Altman, the materialistic Soviets also hated the body and ...Upgrade to Premium to Read the Full Newsletter, Playable Timestamps, AI Powered Answers, Unlock 300+ Premium Posts, No Ads and MOREGo PREMIUMJensen Huang – Founder of Nvidia | Founders Podcast with David Senra What "Strategy" Actually Means: Strategy is not words; strategy is actionWhat "Mission" Actually Means: The Mission is the Boss. Nvidia exists to serve a mission and not for the sake of perpetuating its existenceShip the Whole Cow: Nvidia found ways to package and sell hardware that it previously would have discarded; this helped it mitigate low-end market competition and insulate itself from the innovator’s dilemmaComplacency kills: The enemy is not the competition, but the company falling victim to complacency – both real and imaginedJensen’s keys to success:(1) He puts in more effort than his peers and (2) He has a willingness to tolerate more suffering than those around him* Greatness does not come from intelligence; it comes from character, which can only be earned from overcoming adversities and developing perseveranceHistory’s greatest founders spend a lot of time teaching within their organization* Founders Thread: “If you’re not spending 90% of your time teaching, then you’re not doing your job.” – James Sinegal of Costco* Founders Thread – Apple is Steve Jobs with 10,000 lives* The best founders are evangelists for their companies; examples include Steve Jobs, Palmer Luckey, and Sir James DysonThe Whiteboard Method: Using a whiteboard is the primary form of communication in Nvidia meetings; everyone must demonstrate their thought process in real-time, and be willing to eventually erase an idea – no matter how good it isGo Fast or Die: “You can drive great people away by making the speed of decision-making really slow. Why would great people stay in an organization where they can’t get things done? They look around and say, ‘Hey, I love the mission, but I can’t get my job done because the speed of decision-making is too slow.”Value of A flat organizational structure(1) Enables employees to act with more independence and (2) Filters out low-performing employees who are unaccustomed to thinking for themselvesF Your Feelings: Jensen tortures people into greatness: The quality of the work is the most important thing, not people’s feelings* “I wake up every morning, look at myself in the mirror, and say: ‘You suck.’” – Jensen Huang* “I don’t like giving up on people. I’d rather torture them into greatness.” – Jensen HuangThe Speed of Light in Practice:* Break down each component task of a project and assign a target time to completion for it* Assume no delays, no queues, and no downtime so that you can set the theoretical maximum, i.e. the Speed of Light* Instead of judging performance relative to your past performance or against the competition, judge yourself against the speed of light and the law of physicsTop Five Things (T5T) email* Every employee, at all levels, sends an email with the top five things that they are working on, or the top five things they are observing in the market (customer pain points, a competitor’s strategy, new developments in technology, or project delays)* Each email contains five bullet points, and the first word in each bullet is an action word, such as finalize, build, or secure* Each department labels each email in the email’s subject lineWinston Churchill Would have Loved Twitter/X– He limited the size of memos that his staff could send him and told them that it was “slothful” not to compress your thoughtsHenry Singleton, cofounder of Teledyne, on planning:* 1. Flexibility over rigid plans* 2. Daily steering over long-term planning* 3. Excessive planning constraints freedom of action* 4. Recognize that the world is complex and avoid counterproductive planning* 5. Be skeptical of the herdEducating the Marketplace: If you are doing something brand-new, you must spend a lot of time and resources on educating the market about your new idea or invention Dr. Brian Keating: Charting the Architecture of the Universe & Human Life | Huberman Lab Fun fact #1: We didn’t have accurate clocks until the 1700s. Before that, keeping time on a ship or in different time zones was nearly impossibleFun fact #2: The Gutenberg Bible was used as a standard for vision quality in the past. They would test eyesight by making people read it from a certain distance since it had a fixed font size. This was way before modern eye chartsPineal Gland (get rid of that flouride): Most animals have a pineal gland that secretes melatonin based on light. “This is the intrinsic clock-keeping mechanism of all mammalian species and reptiles.” – Huberman* Birds have thin skulls, so light can pass right through to the pineal gland* Humans are different: Our pineal gland is buried deep in the brain, so light doesn’t reach it directly. Instead, light info gets passed from the eyes through a pathway to the pineal gland.Gender Symmetry: Women are more symmetrical than menEyes Are Outside Brains: Retinas, which line the back of the eyes, are part of the central nervous system and were squeezed out of the brain during early development* Eyes are the only portion of your brain that reside outside the cranial vaultHubble made two major discoveries: that the Milky Way isn’t the entire universe, and that the universe is expanding“The Big Bang is not the origin of time and space, it’s the origin of the first elements in the periodic table.” – BrianThe best places in the Northern Hemisphere to see spectacular nighttime views:* Yosemite High Country in August for meteor showers would be a great option* Anywhere 20-40 miles from a large city should be fine. Even in San Diego, there are two dark sky communities: Julian and Anza-Borrego DesertPanspermia—the idea that life might’ve come from elsewhere in the universe. Basically, genetic material could’ve traveled from one astronomical object to another. This is not something scientists can prove right now, especially with the lack of life evidence elsewhereTools for Managing Stress & Anxiety | Huberman Lab Essentials How breathing affects heart rate:* Inhale:* When you inhale (through the nose or mouth), the diaphragm moves down, and the lungs expand* The heart gets slightly bigger in that expanded space* This increased space causes blood to move more slowly through the heart* A group of neurons called the sinoatrial node in the heart detects the slower blood flow and sends a signal to the brain* The brain then signals the heart to speed up* A longer or more vigorous inhale will make your heart beat faster* Exhaling:* When you exhale, the diaphragm moves up, and the heart becomes smaller and more compact* Blood flows faster through the smaller heart space* The sinoatrial node detects the faster blood flow and signals the brain* The parasympathetic nervous system sends a signal back to the heart to slow down* A longer or more vigorous exhale will make your heart rate slow downThe physiological sigh: two deep inhales through the nose (no exhale in between), followed by a full exhale to the lungs empty (through the mouth) is the fastest way to calm downWhy short-term stress is good:* Pupil dilation and optical changes help enhance vision* Heart rate quickens, improving blood flow and readiness* Cognition sharpens, bringing certain brain areas online to focus better* Narrowed focus supports duration-path-outcome analysis. It allows you to evaluate your environment and decide what to do* It primes the immune system to combat bacterial or viral infectionsTool: eye dilation* Without moving your head or eyes, shift from tunnel vision to panoramic vision (see more of your surroundings)* This activates circuits in the brainstem associated with calming and reduces alertness/stress* For example: While running or cycling at max capacity or 80–90% of your maximum effort, practice dilating your gazeBest tools to modulate long-term stress:* Regular exercise (who would’ve thought!)* Prioritizing good sleep* Using real-time tools to manage stress response (e.g., breathing exercises)* Social connection (one of the most effective ways to combat long-term stress)Theanine (L-theanine):* Recommended dose: 100–200 mg, 30–60 minutes before sleep* Benefits:* Enhances the transition into sleep and improves sleep depth.* Increases GABA, an inhibitory neurotransmitter* Reduces activity in the forebrain, calming thinking and ruminative systems* Stress and anxiety:* Proven to significantly increase relaxation* Shown to have a minor yet notable effect on anxietyTyler Cowen – Humans Are The Bottleneck to AI Progress | Dwarkesh Patel Cost disease and AI: Cost disease happens when wages rise across the board due to productivity gains in some industries, but sectors like healthcare or education, where productivity is harder to improve, still need to pay higher wages—making their costs go upTech diffusion is universally pretty slow: While people in the Bay Area are the smartest, most dynamic, and most ambitious, they tend to overvalue intelligenceSome kind of demoralization may materialize in the AI future: Full employment is likely to remain, but it is not clear what humans will be doing or how happy it will make us.The Risks of Progress: War should always be the main concern during a period of rapid technological progress; throughout history, when new technologies emerge, they are turned into instruments of war, and terrible things can happenPREMIUM:* David Deutsch: Chemical Scum that Dream of Distant Quasars | TED 2005* Scott Galloway on How Stoicism Can Benefit Young Men | Daily Stoic with Ryan Holiday* Mike Cernovich – Escaping Sam Altman’s Techno-Slavery | Zero Hour with James PoulosFREE:* Jensen Huang – Founder of Nvidia | Founders Podcast with David Senra* Dr. Brian Keating: Charting the Architecture of the Universe & Human Life | Huberman Lab* Tools for Managing Stress & Anxiety | Huberman Lab Essentials* Tyler Cowen – Humans Are The Bottleneck to AI Progress | Dwarkesh Patel Thank you for subscribing. 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May 28, 2026

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102

Modern Wisdom: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- I spent a really long time putting this together, I really hope you enjoy it! In this inaugural episode of Mostly Wise, we explore: The non-sexual benefits of tadalafil (Cialis). Why Retardmaxxing might be the most underrated life hack. The strange reasons why people are making AI clones of their exes. Why America is addicted to lawsuits. If Love Island is harder than Navy SEAL selection training. and much more Guests Matt McCusker is a comedian, writer, author, and podcaster Dr Andrew Huberman is a neuroscientist, Associate Professor at the Stanford University School of Medicine and a podcaster. Tom Segura is a comedian, podcaster, and actor. Sponsors: See discounts for all the products I use and recommend: ⁠⁠https://chriswillx.com/deals⁠⁠ Get up to $350 off the Eight Sleep Pod 5 at https://eightsleep.com/modernwisdom Get 35% off your first subscription on the best supplements from Momentous at https://livemomentous.com/modernwisdom Get 160+ lab tests for just $365 and save an extra $25 at https://functionhealth.com/modernwisdom Get 15% off your first order of my favourite Non-Alcoholic Brew at https://athleticbrewing.com/modernwisdom Get ChatGPT to explore ideas, solve problems, and learn faster at ⁠https://chatgpt.com Timestamps: (0:00) Should All Men Be Taking Erectile Dysfunction Medication? (5:24) The GLP-1-Free Way to Get Lean (8:28) Why Comedians Make Great Actors (14:02) What Science Reveals About Comedians (25:33) How Love Island Manipulates Sleep (30:39) Is Retardmaxxing the New Way of Living? (46:28) The Risk of Recreating Your Ex With AI (49:32) Has Surveillance Killed Serial Killers? (52:53) Falling is a Billion-Dollar Industry (57:57) Are NASA Conspiracies Going Too Far? (01:01:05) Are These the Craziest Conspiracy Theories? (01:12:00) The Origins of the Secret Service (01:17:08) Can Cannabis Trigger Psychosis? (01:24:01) Is Nostalgia Ruining the Present? (01:31:10) The Unexpected Benefits of Fap Naps (01:38:38) The Best Method to Optimise Your Sleep (01:45:32) Are Kids Becoming Smarter? (01:57:12) Is Hollywood Exploiting OnlyFans Creators? (01:59:58) Has Chris’ Voice Been Stolen? (02:06:18) Are Clang Associations a Sign of Psychosis? (02:09:57) The Crazy Spending Habits of Johnny Depp (02:15:56) What Happens When You Don’t Sleep? (02:19:19) Are Backyard Ultra Runners the Toughest Athletes? (02:23:04) Can You Get Shredded Sugarmaxxing? (02:25:47) Does the Marshmallow Test Hold Up? (02:31:38) Is Sunscreen Actually Bad For You? (02:40:20) Where to Find the Guys Extra Stuff: Get my free reading list of 100 books to read before you die: ⁠⁠https://chriswillx.com/books⁠⁠ Try my productivity energy drink Neutonic: ⁠⁠https://neutonic.com/modernwisdom⁠⁠ Episodes You Might Enjoy: #577 - David Goggins - This Is How To Master Your Life: ⁠⁠lnkfi.re/SN-Goggins⁠⁠ #712 - Dr Jordan Peterson - How To Destroy Your Negative Beliefs: ⁠⁠lnkfi.re/SN-Peterson⁠⁠ #700 - Dr Andrew Huberman - The Secret Tools To Hack Your Brain: ⁠⁠lnkfi.re/SN-Huberman⁠⁠ - Get In Touch: Instagram: ⁠⁠https://www.instagram.com/chriswillx⁠⁠ Twitter: ⁠⁠https://www.twitter.com/chriswillx⁠⁠ YouTube: ⁠⁠https://www.youtube.com/modernwisdompodcast⁠⁠ Email: ⁠⁠https://chriswillx.com/contact⁠⁠ - Learn more about your ad choices. Visit megaphone.fm/adchoices

February 28, 2026

Martin Shkreli: From Most Hated Man to Optical Computing Visionary – Curiosity & Defiance

James Altucher Show: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- A Note from James:Is he the most hated man in America? I don’t think so.Martin Shkreli was notorious for various reasons that you’ll hear about in this episode—there are some crazy stories—but I’ve come to know Martin over the past few months as both a friend and business partner.Let’s just hear his stories and explanations. I think you’ll agree with me that this is one of the smartest people I’ve ever had on the podcast.Episode Description:Martin Shkreli became one of the most controversial figures in business history—labeled “the most hated man in America,” prosecuted, imprisoned, and publicly vilified.In this conversation, he tells his side of the story.Part 1 focuses on how media narratives form, why conviction and risk-taking matter in entrepreneurship, and the deeper mechanics behind the pharmaceutical controversy that made him famous. He explains the economics of drug pricing, insurance systems, neglected medications, and why public perception diverged so dramatically from what patients actually experienced.The episode also explores learning across disciplines, intellectual courage, prosecutors’ incentives, and how public scandals evolve into legal consequences.Whether you agree with him or not, the discussion raises uncomfortable questions about business, regulation, media, and reputation.What You’ll Learn:Why media narratives can shape public opinion more than factsThe real economics behind pharmaceutical pricing and insurance coverageHow entrepreneurs learn complex industries without formal trainingWhy conviction and risk tolerance are essential in investing and businessHow incentives within legal and political systems influence outcomesTimestamped Chapters:[00:02:00] “Most Hated Man in America” — Media Narratives & Reputation[00:03:11] A Note from James[00:03:45] Humor vs. Backlash: Handling Public Criticism[00:06:39] Conviction, Investing & Standing Your Ground[00:09:00] Optimism, Forgiveness & Business Relationships[00:12:08] The Pharma Controversy Begins[00:14:52] From Hedge Funds to Biotech CEO[00:17:40] Learning New Industries from Scratch[00:19:00] Staying Curious & Avoiding Fear of Complexity[00:21:00] Borrowing Knowledge Across Domains[00:23:06] How People Actually Learn Complex Skills[00:29:00] Entrepreneurship, Ego & Motivation[00:31:20] The Daraprim Pricing Decision Explained[00:34:00] Neglected Drugs & Pharma Economics[00:37:00] Profit Motive vs. Public Good[00:41:13] Why He Became the Target[00:45:00] Prosecutors, Incentives & Legal Strategy[00:47:00] Hedge Funds, Technical Violations & Trials[00:50:00] High-Profile Cases & Selective Enforcement[00:53:00] Media Attention & Personal DecisionsSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

April 26, 2026

Martin Shkreli on AI, Pharma, and What Actually Matters

A16z Podcast: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Erik Torenberg speaks with Martin Shkreli, American investor and businessman, about how he sees the AI landscape, from OpenAI to Anthropic, and what actually matters beyond the hype. They also talk through the future of computing, the limits of “vibe coding,” and why biotech and pharma remain some of the toughest industries to get right. Resources: Follow Martin on X: https://x.com/MartinShkreli Stay Updated:Find a16z on YouTube: YouTubeFind a16z on XFind a16z on LinkedInListen to the a16z Show on SpotifyListen to the a16z Show on Apple PodcastsFollow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.