Cryosphere Podcast

Hosted by Cryosphere Foundation

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Apr 2026

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Chilling thoughts on Cryonics, Biostasis, and related matters. cryospherepress.substack.com

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42 recent

April 26, 202640 min

Cryosphere Chat - Nectome's 12 Minute Rule, CSO Standards, Space Biostasis

Watch the episode on YouTube here.This episode was recorded before the tragic passing of Mike Perry. In this episode of the Cryosphere Chat we discuss:- In which scenarios we'd want to be cryopreserved- Whether Nectome's 12-minute rule is wise- What are the elements of a cryonics Service Organization- The schedule for the Biostasis Summit- Whether interest in space biostasis can help cryonicsLinks:- Buy tickets for the Biostasis days at Vitalist Bay (use code CRYOFRIENDS-50 for 50% off)- Join the Biostasis Summit mailing list- Space Biostasis Coalition- Cryonics Subreddit- Cryosphere Discord This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

February 22, 202629 min

Cryosphere Chat - Tomorrow Bio's Big Announcement, Biostasis Summit Updates

Watch the video version on YouTubeIn this epsiode of the Cryosphere Chat we discuss: * The themes of this year's Biostasis Summit* Our thoughts on Tomorrw Bio's big announcement about longevity experts* Greg Fahy's paper on ultrastructure preservation in vitrified brainsAlso reminder to buy your tickets for the Biostasis Summit on the Vitalist Bay website. Use code CRYOSPHERE20 for 20% off or apply for a larger needs based discount here.Links:* Buy Biostasis Summit tickets* Needs based discount application* Biostasis Summit pitch application* Survey of cryonicists* Cryonics Subreddit* Cryosphere Discord This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

December 22, 202534 min

Cryosphere Chat - Sparks Brain Preservation & GCS 2026

In this epsiode of the Cryosphere chat we discuss:* The next Global Cryonics Summit* What Daniel saw at the Sparks Brain Preservation event* How to sustainably scale up cryonics organizationsTo watch this on video —> Links:Join The Global Cryonics Summit Mailing List: https://www.globalcryonicssummit.com/ This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

November 19, 202549 min

Our BRLS Research Application, Fixation vs. Vitrification Reflection, Cryonics & Autism

Watch the video version on YouTubeIn this epsiode of the Cryosphere Chat we discuss: ● The research proposal we submitted to BRLS● Why slow growth could be an existential risk to cryonics● Our review of the Fixation vs. Vitrification discussion● Why there are so many autistic cryonicistsLinks:Fixation vs. Virtification DiscussionBiostasis Pacific NorthwestI’ll see ya later mom... Reddit postCryosphere Discord This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

November 15, 20251 hr 51 min

Aschwin de Wolf & Andy McKenzie - Fixation vs. Vitrification

There has long been debate in the cryonics community on whether the best procedure for preserving patients is to use chemicals to fixate the brain or to perfuse cryoprotectants and use cryogenic temperatures to vitrify the body (as Alcor, Tomorrow Bio, and Cryonics Institute do). We brought together two of the best researchers in the field to help us understand each procedure including what we care about preserving in the brain, the strengths and weakness of each approach, whether one approach favors biological reanimation vs. brain emulation, and more.Links:* Biostasis Standard Substack: https://biostasis.substack.com/* Andy McKenzie’s Substack: https://neurobiology.substack.com/* Spark’s Brain Preservation: https://sparksbrain.org/* Cryosphere Discord: https://discord.gg/ndshSfQwqz* Reddit: https://www.reddit.com/r/cryonics/ This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

October 18, 202536 min

Cryosphere Chat ft. Emil Kendziorra

The gang catches up with Emil Kendziorra after the Biostasis 2025 conference at the European Biostasis Foundation. Watch it on YouTube here. Topics covered include:* How to get a Tomorrow Bio ambulance in your hometown* Tomorrow Bio’s plan to collect brain samples to check ultra-structure preservation in its patients - and how it will respond to what it finds* What’s new and what’s next for Tomorrow Bio* Our near death experiencesLinks: * Cryosphere Discord Server * Cryonics Subreddit* Cryosphere YouTube Channel This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

September 28, 202546 min

Cryosphere Chat

In this second episode of Cryosphere Chats we discuss Until Labs and Alcor’s organ preservation strategies, our experiences convincing others about cryonics, using terms like hibernation or cryosleep instead of death when explaining cryonics, and more!Watch it on YouTube here. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

September 12, 202541 min

Cryosphere Chat - Replacement Technology, Updates From CI, Why Cryonicists Don’t Have Kids

We’re trying out a new format where the team behind the Cryosphere has an informal discussion on a range of cryonics related topics. Watch the video version on YouTube. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

May 31, 20251 hr 34 min

Is Cryonics a Pseudoscience? - Ariel Zeleznikow-Johnston

In this episode we talked to Ariel Zeleznikow-Johnston, a research fellow at Monash University and author of The Future Loves You. This episode includes considerable debate between the hosts and the guest, as well as participation from a live audience at the Biostasis week at Vitalist Bay.Topics Discussed & Debated: * Why Ariel has used terms like "pseudoscience" "cult-like" and "snake oil" to describe cryonics * Cryopreservation versus vitrifixation * Neuroscientist's sentiments on biostasis for future reanimation * What's the nature of consciousness and the self * Is a brain emulation really "you" in the ways that matter Links: * Ariel Zeleznikow-Johnston: https://www.arielzj.com/ * Cryonics Discord server: https://www.discord.gg/cryosphere * Cryonics subreddit: https://www.reddit.com/r/cryonics/If you prefer to watch this on video, check this link. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

April 6, 20251 hr 1 min

Mark Woodward - A Revolution in Cryoprotectants

In this episode of The Cryosphere Podcast, hosts Max Marty and Rebecca Ziegler sit down with Mark Woodward, founder of Wake Bio, who's applying cutting-edge AI techniques to solve one of cryonics' most fundamental challenges: developing superior cryoprotectants. With a background in AI/ML at Google Brain and Stanford, Mark explains how he's now using machine learning to rapidly explore the chemical landscape in search of compounds that can protect biological tissue during freezing without the toxicity issues that plague current solutions. He's starting with Zebrafish, but his ultimate goal is full body human reanimation. Topics Discussed: -* How AI can accelerate cryoprotectant discovery by helping us navigate chemical combinations* The physics of vitrification and why current cryoprotectants struggle with larger organisms* Wake Bio's methodical approach: starting with zebrafish before progressing to mammals* Why warming tissue needs to happen faster than cooling to prevent ice crystal formation* The debate between biological reanimation versus mind uploading approaches* The practical challenges of transitioning from lab settings to real-world cryopreservation* How Wake Bio's research might eventually revolutionize organ preservation and transplantation* Mark's ambitious five-year goal of successfully preserving adult mice and ten-year vision for human cryopreservationLinks:* Wake Bio's Website: https://wake.bio* Contact: mark [at] wake.bio This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com