The Tea in STEM

Hosted by Anna Fehr and Alexandria Clark

Science Education

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Episodes

Latest episode

Sep 2025

Language

EN-US

About the show

The good, the bad, the dirty of the Science, Technology, Engineering and Math world. New Episodes Weekly!

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50 recent

September 2, 202514 min

Dark History of Clinical Trials Episode 7

In this episode of Dark History, we revisit one of the most infamous studies in clinical research — the Tuskegee Syphilis Study. While nearly every researcher has heard of it as the cornerstone example of why IRBs exist, the deeper story is often reduced to a single sentence in textbooks. For forty years, Black men in Tuskegee, Alabama were denied proper treatment for syphilis — even after penicillin was proven curative — under the guise of “free healthcare.” We’ll unpack not just what happened, but why it was allowed to continue, the systemic racism and exploitation it revealed, and how its legacy continues to shape medical mistrust and research ethics today.

August 25, 202512 min

Dark History of Clinical Trials Part 6

In this episode, we dive into a chilling case where a promising T-cell therapy showed remarkable results in adolescents and pediatric patients — but when tested in adults, the outcome was tragically different. Phase 1 looked fine, Phase 2 turned deadly. To this day, we still don’t fully understand why. Was it biology? Trial design? Or something deeper about the risks of pushing boundaries in science? Join us as we unpack what went wrong, and what this story teaches us about the fragile line between breakthrough and disaster in clinical research.

August 18, 202522 min

All Episodes FDA: F*** Around and Find out Episode 9

“Good Intentions, Bad Paperwork” Meet the city doc everyone loved — champion of public health, hero of harm reduction, and the driving force behind making Narcan accessible without a prescription. But when his passion for helping people collided with the rigid rules of an HIV clinical trial, things got messy. This episode dives into how one man’s altruism, while admirable, ran head-first into FDA regulations, resulting in a 483B. It’s a cautionary tale of how even the best intentions need a protocol to match.

June 30, 20259 min

Dark History of Clinical Trials Part 5

In this powerful installment of Dark History of Clinical Trials, we examine one of the most tragic and transformative episodes in pharmaceutical history: the thalidomide disaster.Marketed as a safe sedative and morning sickness treatment in the late 1950s, thalidomide was distributed to thousands—only to cause severe congenital deformities and pregnancy losses across the globe. This catastrophe exposed critical flaws in drug testing, marketing, and approval processes.In this episode, we uncover:The rise and reckless distribution of thalidomideThe real human cost behind corporate and regulatory failuresHow this tragedy reshaped modern drug approval lawsThe birth of the FDA’s MedWatch program and tighter safety controlsWhy we now distinguish between OTC and controlled medicationsUnderstanding this dark chapter is key to appreciating the safeguards we often take for granted today.

June 10, 202516 min

FDA: F*** Around and Find out Episode 8

In this episode, we dive deep into the recent FDA action that exposed a pharmaceutical manufacturer distributing counterfeit codeine cough syrup. What began as a quiet compliance concern quickly escalated into a full-scale investigation—leading to shutdowns, criminal charges, and regulatory fallout.

May 27, 202518 min

Dark History of Clinical Trials Episode 4

When 26-year-old Markinson suffered a psychotic break, he was given a choice no one should ever face: participate in a clinical trial or face long-term involuntary confinement. What followed was a tragic chain of events—his worsening condition, the helpless fight of a mother trying to save her son, and ultimately, a suicide that would spark a national conversation about ethics, consent, and mental illness in clinical research.In this episode, we examine the heartbreaking story of the Markinson case—a chilling example of how regulatory systems meant to protect can fail the most vulnerable. We explore IRB bias, the complexities of informed consent under duress, and the urgent need for advocacy in mental health trials.

May 12, 202521 min

Dark History of Clinical Trials Episode 3

In this chilling episode of Dark History of Clinical Trials, we explore the devastating 2016 Phase 1 clinical trial in Rennes, France, that left one man dead and several others with lasting neurological damage. Designed to test a new painkiller, the study went catastrophically wrong after investigators escalated the dose without properly analyzing earlier data. We uncover what went wrong, the oversight failures, and how it shook public trust in drug development.This tragedy serves as a sobering reminder of why data review, transparency, and ethical safeguards in early-phase trials are not just protocols—they are matters of life and death.

April 21, 202514 min

Interview: Navigating Clinical Trials in Government-Funded Hospitals (Part 3)

In Part 3 of our series on government-funded clinical trials, we shift the focus to the upsides of working in publicly funded research. From greater patient diversity and broader public health impact to mission-driven work and long-term study follow-through, we highlight what makes this space both rewarding and unique.We also explore what kind of professionals thrive in this environment. Is it the detail-oriented? The mission-focused? The ones who care deeply about equity in access to care?Tune in as we explore why some coordinators and investigators choose this path—and why they stay.

April 7, 202518 min

Interview: Navigating Clinical Trials in Government-Funded Hospitals (Part 2)

In this continuation of our deep dive into government-funded clinical trials, we explore real-world examples of how these studies operate differently from private pharma-sponsored research. Our guest shares firsthand insights into challenges like proving adverse events without medical records, navigating patient compensation differences, and the disconnect between research benchmarks and real-life feasibility. We also discuss the impact of wealth distribution on patient access and trial participation. What happens when hospitals close patient accounts, but research teams still need documentation? How do these trials ensure continuity of care? Join us as we unpack the complexities of conducting research in a government-funded setting.

April 1, 202513 min

Interview: Navigating Clinical Trials in Government-Funded Hospitals Part 1

Part 1: Regulatory In this episode, we sit down with a clinical research coordinator from a government-funded hospital to explore the unique challenges and regulatory differences between publicly funded and private pharmaceutical company-sponsored trials. We discuss key topics such as study selection, start-up timelines, and the distinct approval processes that shape the landscape of government-backed research. How do these differences impact trial efficiency, patient access, and innovation? Tune in for an insider’s perspective on the critical nuances of conducting research outside the private sector. Stay tuned for Part 2.

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