The BioInsights Podcast

Hosted by BioInsights

ScienceInterviews guests

Website RSS feed

Episodes

Latest episode

Jun 2026

Language

EN-GB

About the show

The BioInsights Podcast: discussing the challenges of translating novel biologics from bench to clinic to market.

Listen to episodes

60 recent

June 24, 2026Episode 415 min

From one target to many: how high‑plex ddPCR is changing CGT from development to analytics

Lauren Coyle, Editor, BioInsights, speaks with Christian Overgaard, Senior Field Application Scientist, Bio‑Rad Laboratories, about the technical and practical evolution of droplet digital PCR (ddPCR) and high‑plex multiplexing, covering assay design challenges, vector integration analysis, biodistribution studies, and the emerging role of digital PCR in cell and gene therapy characterization and clinical development.

June 17, 2026Episode 318 min

Beyond one and done: engineering durable, redosable cell‑based gene therapies

The one‑and‑done model has defined gene therapy for a generation. Chris Hopkins thinks it is time to move on. At ASGCT 2026, Abi Pinchbeck spoke with the Co‑founder and CEO of Glafabra Therapeutics on redoseable cell‑based gene therapy, a platform spanning Fabry, Pompe, and Gaucher diseases, and what durable, if not permanent, treatment could mean for patients. A podcast version of this discussion is also available.

May 21, 2026Episode 224 min

Precision by design: engineering site‑specific ADCs with machine learning

Lauren Coyle, Launch Commissioning Editor, Bioconjugate Insights, speaks with Weston Kightlinger, CEO, Ridge Bio, about the challenge of DAR heterogeneity and site specificity in ADC development, Ridge Bio’s ML‑driven enzyme and linker engineering platforms, and what site‑specific conjugation means for the future of ADCs as the field moves beyond oncology.

February 23, 2026Episode 130 min

Crossing the ADC inflection points: what separates clinical success from failure

Lauren Coyle, Launch Commissioning Editor, Bioconjugate Insights , speaks with Antoine Yver, Board Chair, Ona Therapeutics, with more than three and a half decades of experience shaping global cancer drug development. In this conversation, they explore what determines whether an ADC successfully crosses the critical threshold and how teams should rethink dose finding, toxicity, and what it truly takes to set a program up for long-term success in the clinic.

November 6, 2025Episode 824 min

Formulation and delivery of RNA-based vaccines and therapeutics: addressing outstanding questions around safety and purity

In this interview, Róisin McGuigan , Editor, Nucleic Acid Insights , and Jesse Erasmus , Director of Virology at HDT Bio, discuss current challenges and opportunities in RNA safety, manufacturing, and targeted delivery, and the key ongoing obstacles facing viral and LNP-based delivery modalities.

October 27, 2025Episode 733 min

Advancing nucleic acid therapeutics with circular RNA

In this podcast episode, Jokūbas Leikauskas , Editor, BioInsights, speaks to Trevor Hallam , who served as Chief Scientific Officer of Sail Biomedicines until July 2025. The interview, recorded in June 2025, explores advances in RNA therapeutics, particularly circular RNA (circRNA or eRNA) technologies, and how they may help overcome current limitations in delivery, durability, and specificity for applications such as CAR-T cell therapies and autoimmune disease treatment.

October 1, 2025Episode 615 min

Exploring advances in bioconjugation: nanozymes, tissue tropism, and the future of responsive systems

Lauren Coyle (Commissioning Editor, Bioconjugation Insights ) speaks to Vincent Rotello (Distinguished Professor of Chemistry, University of Massachusetts Amherst) about the advantages and limitations of different nanomaterial platforms, and emerging strategies such as tissue tropism and responsive nanozymes that could advance targeted therapeutic and diagnostic delivery.

August 27, 2025Episode 521 min

The promise of antibody-oligonucleotide conjugates for neurological diseases

Lauren Coyle , Launch Commissioning Editor, Bioconjugation Insights , speaks with Kerstin Hofer , Science and People Lead, Roche, about the evolving application of antibody-oligonucleotide conjugates in neurology. She highlights their design, delivery challenges across the blood–brain barrier, and potential to transform CNS diseases.

July 18, 2025Episode 419 min

From innovation to access: bridging gaps in scalability and cold chain precision logistics for advanced therapies

Jokūbas Leikauskas , Editor, BioInsights, speaks to Rohin Iyer , Senior Director, Global Cell and Gene Therapy Operations, Marken, about addressing the complex logistics of cell and gene therapies through global infrastructure, precision, and advanced technologies. They also discuss evolving cold chain needs, regulatory and geopolitical challenges, and the need for scalability.

March 27, 2025Episode 312 min

Enhancing mRNA results through strategic RNA design and quality control

In the last few years, mRNA has moved to the fore in the vaccine and cell and gene therapy fields, and as a result, its successful production for these downstream applications has never been more crucial. In this podcast episode, Róisin McGuigan , Editor, Nucleic Acid Insights , speaks to Ryan Lahr , Senior R&D Scientist, CELLSCRIPT, about design, production, and quality control of synthesized mRNA for translation in cells.

Is this your show?

Claim this listing to keep it up to date, reach guests who want to pitch you, and manage bookings with Guestify.

Claim this listing