Curing with Sound

Hosted by Focused Ultrasound Foundation

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Aug 2026

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Imagine harnessing the power of sound waves to heal the human body–this isn’t science fiction, it’s the reality of focused ultrasound technology. Join the conversation that explores the transformative power of this noninvasive therapy revolutionizing the treatment of nearly 180 diseases and medical conditions and giving hope to patients worldwide. Presented by the Focused Ultrasound Foundation.

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August 11, 2026Episode 5825 min

Ep58: Focused Ultrasound and the Future of Veterinary Cancer Research

In this episode of Curing with Sound, we speak with Nikolaos Dervisis, DVM, PhD, DACVIM, an associate professor of veterinary oncology at Purdue University and Senior Advisor for Veterinary Initiatives at the Focused Ultrasound Foundation.Dr. Dervisis discusses the growing role of focused ultrasound in veterinary medicine and its potential to advance cancer care. He also explores how studying naturally occurring cancers in animals can provide valuable insights into disease biology and treatment response, with implications for both veterinary and human medicine. He also shares updates on two new canine clinical trials investigating focused ultrasound for osteosarcoma and lymphoma, explores the challenges of expanding access to the technology in veterinary medicine, and reflects on the vital contributions of pet owners and their animals to advancing this research. Discussion highlights: The One Medicine Concept: Explore how the biological, clinical, and immunological similarities between cancers in humans and animals create opportunities for focused ultrasound research to advance treatment across species. Innovative Clinical Trials: Learn about two new trials at Purdue University investigating focused ultrasound for osteosarcoma and lymphoma, including its potential to influence tumor behavior and immune response. Overcoming Infrastructure Barriers: Hear about the current challenges in veterinary oncology, including the need for species-specific devices, funding limitations, and the importance of training and awareness within the veterinary community. EPISODE TRANSCRIPT ---------------------------- QUESTIONS? Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances. Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation. FUSF SOCIAL MEDIA LinkedIn X Facebook Instagram TikTok YouTube FUSF WEBSITE https://www.fusfoundation.org FOCUSED ULTRASOUND TREATMENT SITES https://www.fusfoundation.org/the-technology/treatment-sites/ SIGN UP FOR OUR FREE NEWSLETTER https://www.fusfoundation.org/newsletter-signup/ READ THE LATEST NEWSLETTER https://www.fusfoundation.org/the-foundation/news-media/newsletter/ DOWNLOAD "THE TUMOR" BY JOHN GRISHAM (FREE E-BOOK) https://www.fusfoundation.org/read-the-tumor-by-john-grisham/

July 28, 2026Episode 5722 min

Ep57: Cracking the Case of Chronic Back Pain with Focused Ultrasound

In this episode of Curing with Sound, we speak with Jim Rorie, a licensed private investigator from North Carolina whose career and daily life were profoundly affected by chronic low back pain following a multi-vehicle collision. After months of physical therapy and painful nerve block injections, Jim became one of the first patients in the United States to be commercially treated with noninvasive focused ultrasound for his back pain. He shares what led him to the procedure, what the treatment experience was like, and how it has transformed his pain, his work, and his quality of life. Discussion highlights: First-of-its-Kind Device Receives FDA Clearance: In November 2025, the FUSMobile Neurolyser XR system received De Novo clearance from the US Food and Drug Administration (FDA) for the treatment of chronic low back pain. The device, which uses focused ultrasound to ablate sensory nerves in the spinal facet joints, is also approved in Europe, Canada, and the UK. Renewed Hope and Quality of Life: Jim reflects on the difference focused ultrasound has made in his recovery, allowing him to return to his career as a private investigator and regain activities that chronic pain had previously limited. All patient stories featured on the Curing with Sound podcast are personal accounts of an individual’s experience with focused ultrasound treatment. Please be aware that each patient’s situation is unique, and outcomes may vary. The information provided in this story should not be considered as medical advice or a guarantee of specific results. It is important to consult with a qualified healthcare provider to discuss your condition and determine the best treatment options for you. The Focused Ultrasound Foundation does not endorse any specific treatment or medical procedure and encourages all patients to seek professional medical guidance tailored to their individual needs. EPISODE TRANSCRIPT ---------------------------- QUESTIONS? Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances. Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation. FUSF SOCIAL MEDIA LinkedIn X Facebook Instagram TikTok YouTube FUSF WEBSITE https://www.fusfoundation.org FOCUSED ULTRASOUND TREATMENT SITES https://www.fusfoundation.org/the-technology/treatment-sites/ SIGN UP FOR OUR FREE NEWSLETTER https://www.fusfoundation.org/newsletter-signup/ READ THE LATEST NEWSLETTER https://www.fusfoundation.org/the-foundation/news-media/newsletter/ DOWNLOAD "THE TUMOR" BY JOHN GRISHAM (FREE E-BOOK) https://www.fusfoundation.org/read-the-tumor-by-john-grisham/

July 14, 2026Episode 5623 min

Ep56: Demystifying the Regulatory Landscape with Matt Myers, PhD

In this episode of Curing with Sound, we speak with Matt Myers, PhD, a research physicist and founder of Puente Translational Sciences. Dr. Myers spent more than 30 years at the U.S. Food and Drug Administration (FDA), where he helped develop tools to evaluate emerging devices and applications, including focused ultrasound. Drawing on decades of experience, Dr. Myers offers an insider's perspective on the FDA's role in advancing medical innovation and explains how researchers and device developers can work more effectively with regulators to accelerate patient access to new therapies. He discusses his early involvement with the first focused ultrasound submission for uterine fibroids, his important work during the COVID-19 pandemic, and his current efforts to help researchers and manufacturers accelerate the path to market for therapeutic ultrasound devices. Discussion highlights: Working with the FDA: How the FDA collaborates with researchers and manufacturers to improve devices, streamline regulatory pathways, and help bring safe and effective technologies to patients. The Evolving Field of Neuromodulation: Why focused ultrasound neuromodulation is generating growing regulatory interest, and how standardized reporting will strengthen future research and clinical translation. Preparing the Next Generation: Dr. Myers' advice for early-career researchers on developing the technical skills and interdisciplinary expertise needed to succeed in the rapidly evolving field of therapeutic ultrasound. EPISODE TRANSCRIPT ---------------------------- QUESTIONS? Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances. Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation. FUSF SOCIAL MEDIA LinkedIn X Facebook Instagram TikTok YouTube FUSF WEBSITE https://www.fusfoundation.org FOCUSED ULTRASOUND TREATMENT SITES https://www.fusfoundation.org/the-technology/treatment-sites/ SIGN UP FOR OUR FREE NEWSLETTER https://www.fusfoundation.org/newsletter-signup/ READ THE LATEST NEWSLETTER https://www.fusfoundation.org/the-foundation/news-media/newsletter/ DOWNLOAD "THE TUMOR" BY JOHN GRISHAM (FREE E-BOOK) https://www.fusfoundation.org/read-the-tumor-by-john-grisham/

June 23, 2026Episode 5527 min

Ep55: Movement Disorders, Epilepsy and More: The Expanding Impact of Focused Ultrasound

Focused ultrasound is rapidly expanding the boundaries of what is possible in functional neurosurgery. From movement disorders to epilepsy, researchers are exploring how this noninvasive technology can precisely target and treat an expanding range of neurological conditions. In this episode of Curing with Sound, Vibhor Krishna, MD, Associate Professor and Vice Chair of Inpatient Operations in the Department of Neurosurgery at the University of North Carolina, discusses the latest advances in focused ultrasound for neurological disorders. Dr. Krishna shares moving patient stories, reviews newly approved bilateral treatment for Parkinson’s disease, and shares encouraging early findings from a Phase I clinical trial for treatment-resistant epilepsy. The conversation also explores the broader therapeutic landscape for epilepsy and the opportunities ahead as focused ultrasound research continues to advance. Discussion highlights: Incisionless Tremor Relief: Discover how focused ultrasound offers a life-changing, noninvasive option for patients with essential tremor who wish to avoid invasive surgery and implanted hardware. Bilateral Parkinson's Treatment: Learn about the recent FDA approval for ablating the palatothalamic tract (PTT) bilaterally, a staged approach that addresses fluctuating symptoms like stiffness and slowness while potentially reducing medication dependence. Pioneering Epilepsy Trials: Hear promising early results of a Phase I clinical trial using focused ultrasound to reduce seizure frequency in patients with treatment-resistant epilepsy. EPISODE TRANSCRIPT ---------------------------- QUESTIONS? Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances. Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation. FUSF SOCIAL MEDIA LinkedIn X Facebook Instagram TikTok YouTube FUSF WEBSITE https://www.fusfoundation.org FOCUSED ULTRASOUND TREATMENT SITES https://www.fusfoundation.org/the-technology/treatment-sites/ SIGN UP FOR OUR FREE NEWSLETTER https://www.fusfoundation.org/newsletter-signup/ READ THE LATEST NEWSLETTER https://www.fusfoundation.org/the-foundation/news-media/newsletter/ DOWNLOAD "THE TUMOR" BY JOHN GRISHAM (FREE E-BOOK) https://www.fusfoundation.org/read-the-tumor-by-john-grisham/

June 9, 2026Episode 5426 min

Ep54: Exploring Focused Ultrasound Applications in Veterinary Medicine with Ashish Ranjan, PhD

In this episode of Curing with Sound, we speak with Ashish Ranjan, PhD, a professor of radiation oncology and director of the Veterinary Research and Oncology Clinic at the University of Texas Southwestern. Dr. Ranjan discusses how emerging focused ultrasound applications, including histotripsy and sonodynamic therapy, are being used to treat solid tumors in companion animals. He explains how veterinary oncology research contributes to advances in human medicine, shares findings from ongoing clinical studies, and explores the potential of combining focused ultrasound with immunotherapy, radiation therapy, and other cancer treatments. Learn how comparative oncology is helping shape the future of personalized, noninvasive cancer care for both veterinary and human patients. Discussion highlights: The One Health Approach: Learn how studying naturally occurring diseases in companion animals can accelerate therapeutic development, providing a powerful bridge between veterinary and human medicine and helping researchers evaluate new treatments more efficiently. Veterinary Research and Oncology Clinic (VROC): Discover how VROC combines advanced clinical care with cutting-edge research to offer dogs and cats access to innovative cancer treatments. The clinic evaluates emerging technologies, such as focused ultrasound, and other novel therapies, and maintains a strong focus on patient comfort, quality of life, and individualized care. EPISODE TRANSCRIPT ---------------------------- QUESTIONS? Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances. Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation. FUSF SOCIAL MEDIA LinkedIn X Facebook Instagram TikTok YouTube FUSF WEBSITE https://www.fusfoundation.org FOCUSED ULTRASOUND TREATMENT SITES https://www.fusfoundation.org/the-technology/treatment-sites/ SIGN UP FOR OUR FREE NEWSLETTER https://www.fusfoundation.org/newsletter-signup/ READ THE LATEST NEWSLETTER https://www.fusfoundation.org/the-foundation/news-media/newsletter/ DOWNLOAD "THE TUMOR" BY JOHN GRISHAM (FREE E-BOOK) https://www.fusfoundation.org/read-the-tumor-by-john-grisham/

May 19, 2026Episode 5318 min

Ep53: Microbubble Technology and Focused Ultrasound: A Conversation with Sasha Klibanov, PhD

Targeted drug delivery to the brain has long been hindered by the blood-brain barrier, a protective layer that prevents many therapeutic agents from reaching their intended targets. For patients with serious neurological disorders, this challenge can significantly reduce access to potentially effective treatments and limit therapeutic outcomes. In this episode of Curing with Sound, we speak with Sasha Klibanov, PhD, Associate Professor in the Division of Cardiovascular Medicine at the University of Virginia and a pioneering researcher in microbubble technology. Dr. Klibanov discusses the evolution of microbubbles from imaging contrast agents to sophisticated tools for drug delivery. He also explains how focused ultrasound, combined with microbubbles, can safely and temporarily open the blood-brain barrier, creating new opportunities for precision therapies and advancing the potential of immunotherapy. Discussion highlights: Microbubble Technology Explained: Explore how microbubbles evolved from diagnostic imaging tools into powerful agents for precise drug delivery when combined with focused ultrasound. Advancing Immunotherapy: Learn about Dr. Klibanov's collaborative research on using size-sorted microbubbles to optimize the opening of the blood-brain barrier, potentially revolutionizing how we treat complex diseases by enabling targeted immune responses. EPISODE TRANSCRIPT ---------------------------- QUESTIONS? Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances. Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation. FUSF SOCIAL MEDIA LinkedIn X Facebook Instagram TikTok YouTube FUSF WEBSITE https://www.fusfoundation.org FOCUSED ULTRASOUND TREATMENT SITES https://www.fusfoundation.org/the-technology/treatment-sites/ SIGN UP FOR OUR FREE NEWSLETTER https://www.fusfoundation.org/newsletter-signup/ READ THE LATEST NEWSLETTER https://www.fusfoundation.org/the-foundation/news-media/newsletter/ DOWNLOAD "THE TUMOR" BY JOHN GRISHAM (FREE E-BOOK) https://www.fusfoundation.org/read-the-tumor-by-john-grisham/

May 5, 2026Episode 5215 min

Ep52: Now You See It, Now You Don't: A Magician's Tremor Disappears with Focused Ultrasound

Essential tremor is a progressive neurological condition that causes involuntary shaking, often significantly impairing everyday tasks. For many, the loss of fine motor control means giving up lifelong passions and careers. Even simple actions, like buttoning a shirt, eating, or writing, can become overwhelming, leading to frustration, embarrassment, and a diminished quality of life. In this episode of Curing with Sound, we speak with Howard Faber, a Michigan-based magician who spent decades entertaining audiences before essential tremor forced him to step away from the stage. Howard discusses his experience with focused ultrasound, a noninvasive treatment that ultimately transformed his condition. He reflects on his journey with progressively worsening tremors, the turning point when Medicare approved focused ultrasound treatment, and his life-changing experience undergoing the procedure. Today, Howard has returned to performing, having regained complete control of his hands and his life. Discussion highlights: The Impact of Essential Tremor: Discover how Howard's progressive tremors interfered with his daily life and his beloved magic career, leading to moments of embarrassment and the difficult decision to stop performing. A Life-Changing Procedure: Follow Howard's experience undergoing focused ultrasound treatment at the Cleveland Clinic, from the preparation process to the emotional moment he realized his tremor was completely gone. All patient stories featured on the Curing with Sound podcast are personal accounts of an individual’s experience with focused ultrasound treatment. Please be aware that each patient’s situation is unique, and outcomes may vary. The information provided in this story should not be considered as medical advice or a guarantee of specific results. It is important to consult with a qualified healthcare provider to discuss your condition and determine the best treatment options for you. The Focused Ultrasound Foundation does not endorse any specific treatment or medical procedure and encourages all patients to seek professional medical guidance tailored to their individual needs. EPISODE TRANSCRIPT ---------------------------- QUESTIONS? Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances. Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation. FUSF SOCIAL MEDIA LinkedIn X Facebook Instagram TikTok YouTube FUSF WEBSITE https://www.fusfoundation.org FOCUSED ULTRASOUND TREATMENT SITES https://www.fusfoundation.org/the-technology/treatment-sites/ SIGN UP FOR OUR FREE NEWSLETTER https://www.fusfoundation.org/newsletter-signup/ READ THE LATEST NEWSLETTER https://www.fusfoundation.org/the-foundation/news-media/newsletter/ DOWNLOAD "THE TUMOR" BY JOHN GRISHAM (FREE E-BOOK) https://www.fusfoundation.org/read-the-tumor-by-john-grisham/

April 21, 2026Episode 5118 min

Ep51: From Research to Reality: Focused Ultrasound for Brain Tumors and Neurodegenerative Diseases

The blood-brain barrier (BBB) is a vital protective mechanism that shields the brain from harmful substances, but it also poses a significant challenge in treating neurological diseases. For patients with aggressive brain tumors or neurodegenerative conditions, the BBB can prevent life-saving therapies and chemotherapeutic agents from reaching their targets, leaving limited treatment options. In this episode of Curing with Sound, we speak with Ying Meng, MD, PhD, a neurosurgeon and scientist at Sunnybrook Health Sciences Centre and the University of Toronto. Dr. Meng is at the forefront of advancing noninvasive brain therapies, leading efforts to translate preclinical focused ultrasound research into clinical application. She shares insights from groundbreaking clinical trials using focused ultrasound to enable targeted drug delivery across the BBB for conditions such as pediatric gliomas and breast cancer metastases, as well as insights on liquid biopsy biomarkers. Discussion highlights: The Future of Accessible Treatment: Dr. Meng’s perspective on the next decade of innovation, including the potential shift of focused ultrasound procedures from specialized MRI environments to more accessible, bedside settings within standard infusion centers—broadening patient access and improving treatment tolerability. Center of Excellence (COE): Established as a COE in 2016, the Sunnybrook Health Sciences Centre is conducting research for focused ultrasound in neurology, neurosurgery, urology, orthopedics, gynecology, radiation oncology, and biomedical engineering. The COE program recognizes luminary sites for their excellence in translational and clinical research, training, and patient care. EPISODE TRANSCRIPT ---------------------------- QUESTIONS? Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances. Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation. FUSF SOCIAL MEDIA LinkedIn X Facebook Instagram TikTok YouTube FUSF WEBSITE https://www.fusfoundation.org FOCUSED ULTRASOUND TREATMENT SITES https://www.fusfoundation.org/the-technology/treatment-sites/ SIGN UP FOR OUR FREE NEWSLETTER https://www.fusfoundation.org/newsletter-signup/ READ THE LATEST NEWSLETTER https://www.fusfoundation.org/the-foundation/news-media/newsletter/ DOWNLOAD "THE TUMOR" BY JOHN GRISHAM (FREE E-BOOK) https://www.fusfoundation.org/read-the-tumor-by-john-grisham/

April 7, 2026Episode 5041 min

Ep50: Living a Pain-Free Life with Dr. Sanjay Gupta and the Role of Focused Ultrasound with Dr. Lauren Hadley

Chronic pain affects one in five adults, yet it remains a deeply personal and often misunderstood experience. For many, the search for relief becomes a cycle of treatments that fail to deliver lasting results, sometimes leading to long-term reliance on medications that can significantly impact quality of life. In this special episode of Curing with Sound, we examine the future of pain management from three unique perspectives. We begin with renowned neurosurgeon and CNN Chief Medical Correspondent Sanjay Gupta, MD, who shares insights from his latest book, It Doesn’t Have to Hurt: Your Smart Guide to a Pain-Free Life. Dr. Gupta explores how pain is not merely a physical signal, but a complex experience shaped by the brain and nervous system, one influenced by movement, sleep, stress, and daily interactions. The episode also features Lauren Hadley, MD, MBA, the Foundation’s Associate Director of the Research and Education Team, who discusses the science behind focused ultrasound as a noninvasive alternative to traditional surgery and pharmacologic treatments. Finally, we hear from Reginald Masters, a patient whose chronic low back pain was successfully treated with focused ultrasound, offering a compelling firsthand account of life before and after treatment. Discussion highlights: The Neuroscience of Pain: Dr. Sanjay Gupta examines the subjective nature of pain, drawing on years of clinical experience and reporting to shed light on how pain is understood and managed. A Noninvasive Revolution: Dr. Lauren Hadley explains how focused ultrasound is transforming pain treatment by targeting the source through approaches such as thermal ablation and neuromodulation. A Patient’s Journey to Relief: Reginald Masters shares his experience living with debilitating pain for decades and finding rapid relief through a noninvasive focused ultrasound procedure. All patient stories featured on the Curing with Sound podcast are personal accounts of an individual’s experience with focused ultrasound treatment. Please be aware that each patient’s situation is unique, and outcomes may vary. The information provided in this story should not be considered as medical advice or a guarantee of specific results. It is important to consult with a qualified healthcare provider to discuss your condition and determine the best treatment options for you. The Focused Ultrasound Foundation does not endorse any specific treatment or medical procedure and encourages all patients to seek professional medical guidance tailored to their individual needs. EPISODE TRANSCRIPT ---------------------------- QUESTIONS? Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances. Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation. FUSF SOCIAL MEDIA LinkedIn X Facebook Instagram TikTok YouTube FUSF WEBSITE https://www.fusfoundation.org FOCUSED ULTRASOUND TREATMENT SITES https://www.fusfoundation.org/the-technology/treatment-sites/ SIGN UP FOR OUR FREE NEWSLETTER https://www.fusfoundation.org/newsletter-signup/ READ THE LATEST NEWSLETTER https://www.fusfoundation.org/the-foundation/news-media/newsletter/ DOWNLOAD "THE TUMOR" BY JOHN GRISHAM (FREE E-BOOK) https://www.fusfoundation.org/read-the-tumor-by-john-grisham/

March 24, 2026Episode 4913 min

Ep49: Breaking Through Treatment Barriers: Focused Ultrasound for Pancreatic Cancer

Pancreatic cancer remains one of the most difficult cancers to treat, largely because its dense tumor microenvironment makes it difficult for chemotherapy drugs to reach their target. This often leads to poor patient outcomes and underscores the urgent need for new therapeutic strategies to overcome these barriers. In this episode of Curing with Sound, Jae Young Lee, MD, PhD, professor and researcher at Seoul National University Hospital, shares his work exploring focused ultrasound as a noninvasive treatment option for pancreatic cancer. He explains how this technology creates subtle mechanical stress within the tumor, helping to open up its structure so chemotherapy can work more effectively. Dr. Lee also shares encouraging results from his Phase II clinical trial and looks ahead to a pivotal Phase III study, offering new hope for improving patient outcomes. Discussion highlights: A New Treatment Strategy: Focused ultrasound technology shows promise for addressing the unique challenges of pancreatic cancer, enabling precise tumor targeting while preserving critical surrounding structures. From Research to Reality: Learn how Seoul National University Hospital, a designated Focused Ultrasound Center of Excellence, is integrating this technology into clinical care while advancing research across oncology, neurosurgery, and pain management. Seoul National University Hospital Website EPISODE TRANSCRIPT ---------------------------- QUESTIONS? Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances. Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation. FUSF SOCIAL MEDIA LinkedIn X Facebook Instagram TikTok YouTube FUSF WEBSITE https://www.fusfoundation.org FOCUSED ULTRASOUND TREATMENT SITES https://www.fusfoundation.org/the-technology/treatment-sites/ SIGN UP FOR OUR FREE NEWSLETTER https://www.fusfoundation.org/newsletter-signup/ READ THE LATEST NEWSLETTER https://www.fusfoundation.org/the-foundation/news-media/newsletter/ DOWNLOAD "THE TUMOR" BY JOHN GRISHAM (FREE E-BOOK) https://www.fusfoundation.org/read-the-tumor-by-john-grisham/

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